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Josep Rizo (Jose Rizo-Rey) short biography
Selected publications

[1] Rizo, J. (2018) Mechanism of neurotransmitter release coming into focus, Protein Sci., in press
[2] de Jong, A. P. H., Roggero, C. M., Ho, M. R., Wong, M. Y., Brautigam, C. A., Rizo, J., and Kaeser, P. S. (2018) RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing Membranes, Neuron 98, 335-349 e337.
[3] Voleti, R., Tomchick, D. R., Sudhof, T. C., and Rizo, J. (2017) Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release, Proc Natl Acad Sci U S A 114, E8518-E8527.
[4] Prinslow, E. A., Brautigam, C. A., and Rizo, J. (2017) Reconciling isothermal titration calorimetry analyses of interactions between complexin and truncated SNARE complexes, Elife 6, e30286.
[5] Sitarska, E., Xu, J., Park, S., Liu, X., Quade, B., Stepien, K., Sugita, K., Brautigam, C. A., Sugita, S., and Rizo, J. (2017) Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion, Elife 6, e24278.
[6] Xu, J., Camacho, M., Xu, Y., Esser, V., Liu, X., Trimbuch, T., Pan, Y. Z., Ma, C., Tomchick, D. R., Rosenmund, C., and Rizo, J. (2017) Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN, Elife 6, e22567.
[7] Liu, X., Seven, A. B., Camacho, M., Esser, V., Xu, J., Trimbuch, T., Quade, B., Su, L., Ma, C., Rosenmund, C., and Rizo, J. (2016) Functional synergy between the Munc13 C-terminal C1 and C2 domains, elife 5, e13696.
[8] Pan, Y. Z., Quade, B., Brewer, K. D., Szabo, M., Swarbrick, J. D., Graham, B., and Rizo, J. (2016) Sequence-specific assignment of methyl groups from the neuronal SNARE complex using lanthanide-induced pseudocontact shifts, J Biomol NMR 66, 281-293.
[9] Rizo, J., and Xu, J. (2015) The Synaptic Vesicle Release Machinery, Annu. Rev. Biophys 44, 339-367.
[10] Brewer, K. D., Bacaj, T., Cavalli, A., Camilloni, C., Swarbrick, J. D., Liu, J., Zhou, A., Zhou, P., Barlow, N., Xu, J., Seven, A. B., Prinslow, E. A., Voleti, R., Haussinger, D., Bonvin, A. M., Tomchick, D. R., Vendruscolo, M., Graham, B., Sudhof, T. C., and Rizo, J. (2015) Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution, Nat. Struct. Mol. Biol 22, 555-564.
[11] Mukherjee, S., Zheng, H., Derebe, M. G., Callenberg, K. M., Partch, C. L., Rollins, D., Propheter, D. C., Rizo, J., Grabe, M., Jiang, Q. X., and Hooper, L. V. (2014) Antibacterial membrane attack by a pore-forming intestinal C-type lectin, Nature 505, 103-107.
[12] Wang, H., Sun, L., Su, L., Rizo, J., Liu, L., Wang, L. F., Wang, F. S., and Wang, X. (2014) Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3, Mol. Cell 54, 133-146.
[13] Trimbuch, T., Xu, J., Flaherty, D., Tomchick, D. R., Rizo, J., and Rosenmund, C. (2014) Re-examining how complexin inhibits neurotransmitter release, elife 3, e02391.
[14] Xu, J., Bacaj, T., Zhou, A., Tomchick, D. R., Sudhof, T. C., and Rizo, J. (2014) Structure and Ca(2)(+)-binding properties of the tandem C(2) domains of E-Syt2, Structure 22, 269-280.
[15] Su, L., Quade, B., Wang, H., Sun, L., Wang, X., and Rizo, J. (2014) A plug release mechanism for membrane permeation by MLKL, Structure 22, 1489-1500.
[16] Ma, C., Su, L., Seven, A. B., Xu, Y., and Rizo, J. (2013) Reconstitution of the vital functions of Munc18 and Munc13 in neurotransmitter release, Science 339, 421-425.
[17] Rizo, J., and Sudhof, T. C. (2012) The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices-Guilty as Charged?, Annu. Rev. Cell Dev. Biol 28, 279-308.
[18] Rizo, J. (2012) Cell biology. Staging membrane fusion, Science 337, 1300-1301.
[19] Kaeser, P. S., Deng, L., Wang, Y., Dulubova, I., Liu, X., Rizo, J., and Sudhof, T. C. (2011) RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction, Cell 144, 282-295.
[20] Ma, C., Li, W., Xu, Y., and Rizo, J. (2011) Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex, Nat. Struct. Mol. Biol 18, 542-549.
[21] Sheard, L. B., Tan, X., Mao, H., Withers, J., Ben-Nissan, G., Hinds, T. R., Kobayashi, Y., Hsu, F. F., Sharon, M., Browse, J., He, S. Y., Rizo, J., Howe, G. A., and Zheng, N. (2010) Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor, Nature 468, 400-405.
[22] Shin, O. H., Lu, J., Rhee, J. S., Tomchick, D. R., Pang, Z. P., Wojcik, S. M., Camacho-Perez, M., Brose, N., Machius, M., Rizo, J., Rosenmund, C., and Sudhof, T. C. (2010) Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis, Nat. Struct. Mol. Biol 17, 280-288.
[23] Xue, M., Craig, T. K., Xu, J., Chao, H. T., Rizo, J., and Rosenmund, C. (2010) Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity, Nat. Struct. Mol. Biol 17, 568-575.
[24] Gerber, S. H., Rah, J. C., Min, S. W., Liu, X., de, W. H., Dulubova, I., Meyer, A. C., Rizo, J., Arancillo, M., Hammer, R. E., Verhage, M., Rosenmund, C., and Sudhof, T. C. (2008) Conformational switch of syntaxin-1 controls synaptic vesicle fusion, Science 321, 1507-1510.
[25] Xue, M., Ma, C., Craig, T. K., Rosenmund, C., and Rizo, J. (2008) The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function, Nat. Struct. Mol. Biol 15, 1160-1168.
[26] Dulubova, I., Khvotchev, M., Liu, S., Huryeva, I., Sudhof, T. C., and Rizo, J. (2007) Munc18-1 binds directly to the neuronal SNARE complex, Proc. Natl. Acad. Sci. U. S. A 104, 2697-2702.
[27] Dai, H., Shen, N., Arac, D., and Rizo, J. (2007) A Quaternary SNARE-Synaptotagmin-Ca(2+)-Phospholipid Complex in Neurotransmitter Release, J. Mol. Biol 367, 848-863.
[28] Yang, M., Li, B., Tomchick, D. R., Machius, M., Rizo, J., Yu, H., and Luo, X. (2007) p31comet blocks Mad2 activation through structural mimicry, Cell 131, 744-755.
[29] Rizo, J., and Rosenmund, C. (2008) Synaptic vesicle fusion, Nat. Struct. Mol. Biol 15, 665-674.
[30] Arac, D., Chen, X., Khant, H. A., Ubach, J., Ludtke, S. J., Kikkawa, M., Johnson, A. E., Chiu, W., Sudhof, T. C., and Rizo, J. (2006) Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids, Nat. Struct. Mol. Biol 13, 209-217.
[31] Lu, J., Machius, M., Dulubova, I., Dai, H., Sudhof, T. C., Tomchick, D. R., and Rizo, J. (2006) Structural Basis for a Munc13-1 Homodimer to Munc13-1/RIM Heterodimer Switch, PLoS. Biol 4, e192.
[32] Tang, J., Maximov, A., Shin, O. H., Dai, H., Rizo, J., and Sudhof, T. C. (2006) A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis, Cell 126, 1175-1187.
[33] Rizo, J., Chen, X., and Arac, D. (2006) Unraveling the mechanisms of synaptotagmin and SNARE function in neurotransmitter release, Trends Cell Biol 16, 339-350.
[34] Basu, J., Shen, N., Dulubova, I., Lu, J., Guan, R., Guryev, O., Grishin, N. V., Rosenmund, C., and Rizo, J. (2005) A minimal domain responsible for Munc13 activity, Nat. Struct. Mol. Biol 12, 1017-1018.
[35] Dulubova, I., Lou, X., Lu, J., Huryeva, I., Alam, A., Schneggenburger, R., Sudhof, T. C., and Rizo, J. (2005) A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?, EMBO J 24, 2839-2850.
[36] Garcia, J., Gerber, S. H., Sugita, S., Sudhof, T. C., and Rizo, J. (2004) A conformational switch in the Piccolo C2A domain regulated by alternative splicing, Nat. Struct. Mol. Biol 11, 45-53.
[37] Dai, H., Shin, O. H., Machius, M., Tomchick, D. R., Sudhof, T. C., and Rizo, J. (2004) Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4, Nat. Struct. Mol. Biol 11, 844-849.
[38] Luo, X., Tang, Z., Xia, G., Wassmann, K., Matsumoto, T., Rizo, J., and Yu, H. (2004) The Mad2 spindle checkpoint protein has two distinct natively folded states, Nat. Struct. Mol. Biol 11, 338-345.
[39] Chen, X., Tomchick, D. R., Kovrigin, E., Arac, D., Machius, M., Sudhof, T. C., and Rizo, J. (2002) Three-dimensional structure of the complexin/SNARE complex, Neuron 33, 397-409.
[40] Yamaguchi, T., Dulubova, I., Min, S. W., Chen, X., Rizo, J., and Sudhof, T. C. (2002) Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif, Dev. Cell 2, 295-305.
[41] Dulubova, I., Yamaguchi, T., Gao, Y., Min, S. W., Huryeva, I., Sudhof, T. C., and Rizo, J. (2002) How Tlg2p/syntaxin 16 'snares' Vps45, EMBO J 21, 3620-3631.
[42] Luo, X., Tang, Z., Rizo, J., and Yu, H. (2002) The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20, Mol. Cell 9, 59-71.
[43] Fernandez-Chacon, R., Konigstorfer, A., Gerber, S. H., Garcia, J., Matos, M. F., Stevens, C. F., Brose, N., Rizo, J., Rosenmund, C., and Sudhof, T. C. (2001) Synaptotagmin I functions as a calcium regulator of release probability, Nature 410, 41-49.
[44] Fernandez, I., Arac, D., Ubach, J., Gerber, S. H., Shin, O., Gao, Y., Anderson, R. G., Sudhof, T. C., and Rizo, J. (2001) Three-dimensional structure of the synaptotagmin 1 c(2)b-domain. Synaptotagmin 1 as a phospholipid binding machine, Neuron 32, 1057-1069.
[45] Dulubova, I., Yamaguchi, T., Wang, Y., Sudhof, T. C., and Rizo, J. (2001) Vam3p structure reveals conserved and divergent properties of syntaxins, Nat. Struct. Biol 8, 258-264.
[46] Dulubova, I., Sugita, S., Hill, S., Hosaka, M., Fernandez, I., Sudhof, T. C., and Rizo, J. (1999) A conformational switch in syntaxin during exocytosis: role of munc18, EMBO J 18, 4372-4382.
[47] Ubach, J., Garcia, J., Nittler, M. P., Sudhof, T. C., and Rizo, J. (1999) Structure of the Janus-faced C2B domain of rabphilin, Nat. Cell Biol 1, 106-112.
[48] Shao, X., Fernandez, I., Sudhof, T. C., and Rizo, J. (1998) Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change?, Biochemistry 37, 16106-16115.
[49] Zhang, X., Rizo, J., and Sudhof, T. C. (1998) Mechanism of phospholipid binding by the C2A-domain of synaptotagmin I, Biochemistry 37, 12395-12403.
[50] Ubach, J., Zhang, X., Shao, X., Sudhof, T. C., and Rizo, J. (1998) Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain?, EMBO J 17, 3921-3930.
[51] Rizo, J., and Sudhof, T. C. (1998) C2-domains, structure and function of a universal Ca2+-binding domain, J. Biol. Chem 273, 15879-15882.
[52] Fernandez, I., Ubach, J., Dulubova, I., Zhang, X., Sudhof, T. C., and Rizo, J. (1998) Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A, Cell 94, 841-849.
[53] Shao, X., Li, C., Fernandez, I., Zhang, X., Sudhof, T. C., and Rizo, J. (1997) Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switch, Neuron 18, 133-142.
[54] Rizo, J., Sutton, R. B., Breslau, J., Koerber, S. C., Porter, J., Hagler, A. T., Rivier, J. E., and Gierasch, L. M. (1996) A novel conformation in a highly potent, constrained gonadotropin-releasing hormone antagonist, Journal of the American Chemical Society 118, 970-976.
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