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Microtubule dynamics: structure, mechanism, regulation   Microtubule dynamics: structure, mechanism, regulation

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The contribution of αβ-tubulin curvature to microtubule dynamics
Brouhard, GJ and Rice LM.
J Cell Bio 2014 Nov 10;207(3):323-334. doi: 10.1083/jcb.201407095

A tethered delivery mechanism explains the catalytic action of a microtubule polymerase
Ayaz P, Munyoki, S, Geyer, EA, Piedra FA, Vu ES, Bromberg R, Otwinowski Z, Grishin NV, Brautigam CA, Rice LM.
eLife. 2014 August 5;3:e03069. doi: 10.7554/eLife.03069

Biggest TOG ever?
Get your motor running ...

Regulation of microtubule motors by tubulin isotypes and post-translational modifications
Sirajuddin M, Rice LM, Vale RD.
Nature Cell Biology. 2014 April;16:335-44. doi: 10.1038:ncb2920

TOG cloud

A TOG:αβ-tubulin complex structure reveals conformation-based mechanisms for a microtubule polymerase
Ayaz P, Ye X,Huddleston P, Brautigam CA, Rice LM.
Science. 2012 August 17;337:857-860.

TOGs bind curved tubulin
Mmm, recombinant tubulin Design, overexpression, and purification of polymerization-blocked yeast αβ-tubulin mutants.
Johnson V, Ayaz P, Huddleston P, Rice LM.
Biochemistry. 2011 Oct 11;50(40):8636-44. Epub 2011 Sep 16.
The lattice as allosteric effector: structural studies of alphabeta- and gamma-tubulin clarify the role of GTP in microtubule assembly.
Rice LM, Montabana EA, Agard DA.
Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5378-83. Epub 2008 Apr 3.
Go Justin The structure of the gamma-tubulin small complex: implications of its architecture and flexibility for microtubule nucleation.
Kollman JM, Zelter A, Muller EG, Fox B, Rice LM, Davis TN, Agard DA.
Mol Biol Cell. 2008 Jan;19(1):207-15. Epub 2007 Oct 31.
Go Justin Insights into microtubule nucleation from the crystal structure of human gamma-tubulin.
Aldaz H, Rice LM, Stearns T, Agard DA.
Nature. 2005 May 26;435(7041):523-7.