Microtubules are essential, dynamic polymers of αβ-tubulin that are responsible for chromosome segregation, that have key roles in organizing the interior of eukaryotic cells, and that are the direct targets of anti-cancer therapeutics.
We are interested in discovering the connections between biochemical and structural properties of αβ-tubulin and the complex behavior that emerges from their collective interactions. This is a fascinating frontier problem that challenges our ability to integrate 'one molecule at a time' views of biochemistry and structure with lower resolution measurements of collective behavior spanning different length and time scales.
Our studies take advantage of our ability to create and purify mechanistically defining mutants of αβ-tubulin. We combine structure, biochemistry, imaging, and computation.