Microtubules are essential, dynamic polymers of
αβ-tubulin that are responsible for chromosome
segregation, that have key roles in organizing the
interior of eukaryotic cells, and that are the
direct targets of anti-cancer therapeutics.
We are interested in discovering the connections
between biochemical and structural properties of
αβ-tubulin and the complex behavior that emerges
from their collective interactions. This is a
fascinating frontier problem that challenges our
ability to integrate 'one molecule at a time'
views of biochemistry and structure with lower
resolution measurements of collective behavior
spanning different length and time scales.
Our studies take advantage of our ability to
create and purify mechanistically defining mutants
of αβ-tubulin. We combine structure, biochemistry,
imaging, and computation.